He soon moved on to his first regular feature, the Sons of the Tiger feature in the book the Deadly Hands of Kung Fu.
He began drawing the Avengers in 1975, then added work on the Fantastic Four. He also began work for DC in the 1980s, drawing Justice League of America, which meant he had locked up the art for the most popular heroes of the era.
In 2014, he drew his last regular series, the Sirens miniseries for BOOM!
In 2017, Pérez was inducted into The Will Eisner Award Hall of Fame. In 2019, he officially retired from regular comic book art citing ill health.